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Pathogenic
You are a disease. Infect the human body as a lone pathogen in this cellular roguelike shooter. Collect organelles to evolve your parasite in a microscopic arms race against your host's immune system. Conquer a beautiful, procedurally generated world of tiny proportions.
93% of 4,894 Steam reviews positive
At a glance
● Pros
- Steam reviews: "Very Positive" (93%)
- English supported
- Co-op with friends
- Full controller support
- Steam Deck Verified
● Cons
No notable downsides in the data.
Great for
- Playing with friends or a partner
- Fans of punchy combat and action
- Discovering distinctive indie games
Summarized automatically from Steam reviews, Metacritic, language support, price and spec data.
What players talk about
How often each topic comes up in 57 Steam reviews (English, Korean, Japanese, Chinese) · 86% of them recommend the game
- Difficulty👍 7 👎 3
- Graphics👍 7 👎 1
- Price👍 8
- Controls👍 4 👎 3
- Story👍 5
- Combat & action👍 3
- Music & sound👍 3
- Freedom & exploration👍 3
- Amount of content👍 3
Counts how many reviews mention each topic, split by whether the review recommends the game.
“I recommend the game at the $10 price point. The game is fun, and you get your money's worth.”
About the game
CELLULAR COMBAT EVOLVED
In Pathogenic, you are the disease. Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and conquer your human host.
To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction. Create powerful, game-breaking builds and become the ultimate pathogen.
CREATE YOUR OWN PATHOGEN
Loot, graft, and assemble your parasite from dozens of unique organelles. Combine flagella for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Chain organelle effects and discover powerful synergies to build an unstoppable disease vector.
FIGHT THE IMMUNE SYSTEM
Battle a diverse roster of enemies, from basic immune cells like macrophages and T cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.
METAPROGRESSION
Collect plasmid fragments to permanently upgrade your parasite's plasmid tree between runs. Each parasite will have it's own upgrade tree allowing for a range of builds to suit your preferred playstyle.
EXPLORE A MICROSCOPIC WORLD
Navigate the procedurally generated organic landscape of the human body. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.
FEEL THE ORGANIC ACTION
Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures endless variety - each run offers a fresh and challenging gameplay experience.
JOIN OUR COMMUNITY ON DISCORD
Source: Steam store page (provided by the developer/publisher)
PC requirements
Minimum
Requires a 64-bit processor and operating system OS: Windows 10 64-bit Processor: Intel Core i5-6500 / AMD Ryzen 3 1200 or equivalent Memory: 8 GB RAM Graphics: GeForce GTX 1050 / Radeon RX 560 DirectX: Version 12 Storage: 2 GB available space
Recommended
Requires a 64-bit processor and operating system
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Updated October 27, 2026 · Source: Steam